
Проучванията в областта на противотуморната имунотерапия се развиват в посока на по-насочени стратегии
Откритията в изследванията на имунната система са помогнали за усъвършенстването на имунотерапевтичните стратегии към по-насочени.1,2
Разработване на по-персонализиран подход в изследванията на противотуморната имунотерапия
С развитието на по-насочените стратегии, изследванията се фокусират върху идентифицирането на предиктори на индивидуален имунен отговор чрез специфични туморни характеристики и фактори в туморната микросреда, като:
- Наличието на имунни клетки, инфилтриращи тумора8
- Способността на имунните клетки да инфилтрират туморната микросреда може да бъде основен критерий за различни имунно-насочени терапии, и може да определи кои тумори по-вероятно ще отговорят.
- Модели на генна експресия в туморите, особено гени, участващи в имунния отговор9
- Протеинова експресия на клетъчната повърхност
- PD-L1 експресия на туморните клетки и имунни клетки, инфилтриращи туморите10,11
- MUC1 експресия на туморните клетки12
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Референции:
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- Okita Y, Tanaka H, Ohira M, et al. Role of tumour-infiltrating CD11b+ antigen-presenting cells in the progression of gastric cancer. J Surg Res. 2014;186:192-200. PMID: 24120241
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- Gao Q, Wang XY, Qiu SJ, et al. Overexpression of PD-L1 significantly associates with tumour aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res. 2009;15:971-979. PMID: 19188168
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- Noonan K, Matsui W, Serafini P, et al. Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors. Cancer Res. 2005;65:2026-2034. PMID: 15753403
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